Seattle begins the defense of its crown when it hosts the at 8:20 p.m. ET in the 2026 Wednesday evening schedule, including the finale of the three-game series at American Family Field between the major league-best (90-56) and National League Central-rival (81-65) at 7:40 p.m. ET. The Brewers, who are nine games ahead of the Cubs in the division, are looking to complete a sweep and finish at 9-4 in the season series. Chicago has lost three straight overall and is just three games in front of the for the second NL wild card.
Another team seeking a three-game sweep is the two-time defending World Series champion (88-57), who aim for their season-high seventh consecutive victory when they face the (69-76) at 10:10 p.m. ET at Dodger Stadium. The Dodgers edged the Reds 3-2 on Tuesday to maintain their 10.5-game lead over the Diamondbacks in the NL West and move three ahead of the for the No. 2 seed in the senior circuit.
One day after having their five-game winning streak halted, the (80-66) attempt to take the rubber game of their three-game series against the major league-worst (55-90) at 6:45 p.m. ET at Fenway Park. Boston, which has a firm hold on the second wild-card spot in the American League, sustained a 6-1 loss on Tuesday after having allowed a total of three runs over its previous four contests.
The (82-62) continue their pursuit of a division title when they host the (55-89) at 7:05 p.m. ET in the middle contest of their three-game set at Yankee Stadium. New York, which sits atop the Wild Card standings but trails the AL East-leading by four games, won the opener 5-3 despite an 0-for-3 performance by in his return from an absence of three-plus months due to a fractured rib.
The Seahawks are 3-point favorites against the Patriots in the latest consensus favorites versus the Cubs in the latest consensus favorites over the Reds. The Red Sox are huge -216 favorites against the Angels for fans who want to wager at the -- Model: Seahawks ML (-175) | Expert: Over 19.5 receiving yards (-113, Larry Hartstein)
The Patriots are 5-0 in season openers following a loss in the Super Bowl, but the Seahawks ended last campaign with 10 consecutive victories and have won their last four meetings with New England. The SportsLine Projection Model thinks both streaks will continue as the Seahawks emerge victorious in 73% of its simulations. The Patriots added a pair of top-notch receivers in A.J. Brown and during the offseason, which means not as much attention will be given to DeMario Douglas. SportsLine expert Larry Hartstein likes the 25-year-old Douglas, who made five catches for 45 yards against Seattle in Super Bowl LX, to register at least 20 yards in the 2026 NFL Kickoff Game as one of his favorite :MLB best bets, where to watch
Angels at Red Sox
Time: 6:45 p.m. | Location: Boston | TV: MLB.TV | Stream: (Try for free)
pick is the Under, which is hitting well over 54% of the time. SportsLine expert Adam Thompson (29-13, +1365 on his last 42 MLB picks) is backing the Red Sox to win by multiple runs as the Angels have scored a total of five runs in right-hander last four starts.Rockies at Yankees
Time: 7:05 p.m. | Location: Bronx, N.Y. | TV: MLB Network | Stream: (Try for free)
