Eli Drinkwitz has a new quarterback in tow, as transfer takes the reins for the No. 23 Tigers. He was impressive in his Mizzou debut, throwing for 252 yards and four touchdowns in the first half before being taken out for the rest of the contest. , the Tigers' top holdover at receiver, had 107 yards and two scores. Lance Leipold enters his sixth season at Kansas, and after a nine-win season in 2023, he's failed to reach bowl eligibility in each of the last two seasons. Before making your wagers on Missouri vs. Kansas on Friday, take a look at what the SportsLine Projection Model is saying about this matchup.
The model simulates every FBS game 10,000 times. It is on a 33-20 run on top-rated CFB money-line picks on could have seen strong returns.Missouri vs. Kansas betting odds (via DraftKings)
| Missouri vs. Kansas money line: | Missouri -218, Kansas +180 |
| Missouri vs. Kansas over/under: | 50.5 (Over -110, Under -110) |
| Missouri vs. Kansas spread: | Missouri -5.5 |
Missouri vs. Kansas betting preview
Mizzou's 29 wins over the last three seasons, including two bowl wins, rank fifth among SEC programs, with only , , Ole Miss and winning more. Drinkwitz has registered two double-digit win campaigns in the last three years, but things unraveled in 2025 after a 5-0 start. Part of that opening surge was a win over Kansas in Columbia, highlighted by two touchdowns and ' game-sealing 63-yard touchdown run. Both Norfleet and Roberts are back for 2026, but Mizzou is still going to be without top running back . Hardy is recovering from a gunshot injury he suffered in the offseason, and while he's cleared to practice, Drinkwitz has said he needs to see sustained work in order for the star to participate in a game.The Jayhawks turn things over to , who was behind Jalon Daniels on the depth chart a season ago. Marshall was solid in the Week 1 win over Long Island, throwing for 246 yards and two touchdowns while adding 49 yards on the ground. Kansas' top skill players have changed from 2025, but transfer receiver looks like a threat after logging 130 yards and a score in the 51-6 victory.
