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‘You don’t wanna get burned’: As Patrick Mahomes, Bo Nix return, NFL defensive minds split on how to game-plan for QBs in first game back from injury

One notable suggestion: “Blitz they ass. Get after they ass because that’ll be the first chance having live bullets. You can simulate that all you want, but that’s not football. ... So you get after that ass and you blitz.

‘You don’t wanna get burned’: As Patrick Mahomes, Bo Nix return, NFL defensive minds split on how to game-plan for QBs in first game back from injury
Reid added that Mahomes has "shown everything" in preseason work, running and throwing as normal albeit with the addition of a knee brace.

So as two teams whom

"But you don't wanna get burned the hard way when they're healthier than you think. "

The cases for, against defenses trying to capitalize on QB injury 

Broncos veteran edge rusher

Accelerating rehabilitation timelines leaves some defensive opponents wary of underestimating players' physical resilience. Others cite the psychological element of rehabilitation for athletes disciplined enough to thrive professionally. That "innate competitor" trait that helped them reach these professional heights can't be understated, Seattle Seahawks defensive coordinator Aden Durde said.

Cowboys defensive pass game coordinator Derrick Ansley broke down his tactical expectation for Mahomes and Nix.

"Most of these guys are going to play on-platform anyway," said Ansley, who also coaches Cowboys defensive backs. "Pat's always been quicker than fast, so he's still going to have that instinct. Same thing with Bo. There's no real advantage. …

"My opinion: Just scout it straight up and start with what they do well from past film. "

DENVER, COLORADO - JANUARY 17: Bo Nix #10 of the Denver Broncos tosses the ball during an NFL divisional playoff football game against the Buffalo Bills at Empower Field at Mile High on January 17, 2026 in Denver, Colorado. (Photo by Perry Knotts/Getty Images)
Bo Nix led the Broncos to an overtime postseason victory against the Bills. A broken ankle sidelined him for the AFC championship game. (Photo by Perry Knotts/Getty Images)

(Perry Knotts via Getty Images)

Eight of the coaches and players believed injury layoffs create opportunity.

Defenders and coaches cited movement as a key cue they'd look for in facing Mahomes or Nix in Week 1. Is the quarterback moving more fluidly to his left or the right? If one looks weaker, try to force them in that direction. Does the quarterback move outside the pocket by choice? Some surveyed voted to sit back and test the quarterback's appetite for movement, while others advocated instead for pushing the pocket early.

"Different people give off different keys, so you just want to read your keys," Seahawks edge rusher

Defensive backs surveyed were eager to join their front-seven teammates in creating pressure on a quarterback.

"And then once they get the jitters, it could be wraps. "

What tells will Broncos, Chiefs look for in their chess match?

Expect each defense to test quarterbacks early in the game. But just because a test hasn't come by, say, halftime, doesn't mean it won't come later.

"If you can have that little extra waiting that he hasn't seen, I think that's important for guys like that," said

In between those early tests and the later ones, each defense must heed not only the opposing quarterback's health but also the shifting pieces around him.

The Broncos enter this season with a remarkably consistent roster from last year but change in two key offensive areas: play-caller and receiver.

"He'll throw a lot of different things at you and make you respond. We're going to be ready for it but also have to adjust. "

"Maybe I'll have to slide a little differently, but other than that, I'll be able to go out there and play. "

Nix and Mahomes both will be able to go out there to play, validating the NFL schedule-makers' May decision to stage this game in a standalone prime-time window.

NFL fans will be watching Nix's ankle and Mahomes' knee closely. Chiefs and Broncos defenders, too, will be on alert for any tells.

"Obviously I want to test him and see if he's still Patrick and if he's moving like Patrick because the best thing he did was play off schedule," Broncos defensive coordinator Vance Joseph said. "That's always our calling card is to make quarterbacks move off the spot and make them run for their lives. So we'll see if he can do that. But nothing different.

"I wouldn't pressure him more often than not because sometimes, when you pressure a veteran quarterback, it makes it easy for him. …

"Nothing really schematically different, but obviously [got] to get him off his mark and see if he's Patrick. "

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