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Miami's Malik Willis will duel with Kirk Cousins, as the veteran gets the starting nod over Fernando Mendoza. Vegas, who went 7-10 ATS last year, is a 3-point favorite per the latest Week 1 NFL odds. on top-rated NFL picks since its inception. The model enters the 2026 NFL season on a 53-37 run on top-rated picks dating back to 2024. Anybody following its picks at and NFL betting lines and locked in betting picks for every NFL matchup. is that the Jaguars (-8.5, 40) cover at home versus Cleveland in a Sunday 1 p.m. ET kickoff. The model has the Jags prevailing versus the spread well over 50% of the time, continuing the success they had last year with a league-best 12-5 ATS mark in the regular season. Jacksonville was even more proficient versus the line at home, covering in 78% of games, also the best record in the NFL, while Cleveland was 2-6 ATS on the road, which was the second-worst mark in the NFL. SportsLine's model also has the Over hitting in 63% of simulations. :
Another one of its Week 1 NFL predictions: the Eagles (-5.5, 44.5) cover versus the Commanders on Sunday at 4:25 p.m. ET. Philadelphia has won eight of its last nine versus Washington in games that Jalen Hurts has started and finished. He should have continued production versus Washington's defense which ranked dead last in yards allowed last year and is in transition, with up to eight new starters and moving from a 4-3 base to a 3-4. Add in that Jayden Daniels may use his legs less to avoid the injuries he suffered in 2025, and the fact that Commanders left tackle Laremy Tunsil (triceps) is out, and Philly is forecasted to cover the spread in 60% of simulations in an A-rated pick. .
So what Week 1 NFL picks can you make with confidence, and which underdogs should you lock in now? Check out the latest NFL odds below, then