The Titans lost a pair of players to season-ending injuries in their preseason opener on Thursday.
Head coach Robert Saleh told reporters on Saturday that tight end Jaren Kanak and defensive end Jaylen Harrell are out for the year. Kanak tore his pectoral and Harrell suffered a torn ACL.
Kanak was a seventh-round pick this year out of Oklahoma. He had a tackle on special teams against the 49ers and played five total snaps.
Harrell was a seventh-rounder in 2024. He had 38 tackles, 4.5 sacks and a forced fumble in 34 games the last two seasons and he had two tackles in Thursday's game.