Sep 10, 2026, 6:03 AM3 views

Rams vs. 49ers prediction, odds, time: 2026 NFL Australia game picks from proven model

SportsLine's model simulated San Francisco 49ers vs. Los Angeles Rams 10,000 times and reveals its best bets for Thursday

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SportsLine's projection model has revealed its San Francisco 49ers vs. Los Angeles Rams picks for the 2026 NFL Week 1 game from Melbourne, Australia

Sep 9, 2026 at

8:33 pm ET • 2 min read

NFC West contenders open their regular seasons when the battle the in the 2026 NFL Australia Week 1 matchup in Melbourne on Thursday. Both teams tied for second in the division with 12-5 records last year. The Rams fell short to the eventual champion Seattle Seahawks 31-27 in the NFC Championship Game. The Niners also were eliminated by the Seahawks, losing 41-6 in a divisional round matchup. Aaron Donald will not play for the Rams this week as he continues to condition following his return from a two-year retirement. Visit our :

Kickoff is at 8:35 p.m. ET from Melbourne Cricket Ground. The latest Rams vs. 49ers odds have Los Angeles as 3.5-point favorites, while the over/under for total points scored is 48.5. Before making any 49ers vs. Rams picks, be sure to on top-rated could have seen strong returns.

Now, the model has zeroed in on Here are several 49ers vs. Rams spreadRams -3.5 49ers vs. Rams over/under48.5 points49ers vs. Rams money line Rams -204, 49ers +17249ers vs. Rams picks Kalshi promo code review and :

Top 49ers vs. Rams predictions

After 10,000 simulations of 49ers vs. Rams, the model is going Over 48.5 combined points at .

How to make 49ers vs. Rams picks

In addition to going Over on the total, the model also says one side of the spread hits nearly 60% of the time. Visit SportsLine now to see which side of the 49ers vs. Rams spread you need to jump, all from the model that is 53-37 on top-rated picks since 2024, and find out.

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