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Oregon vs. Oklahoma State prediction, odds, time: 2026 Week 2 college football picks by proven model

SportsLine's computer model reveals its Oklahoma State vs. Oregon picks for the Saturday college football matchup

Oregon vs. Oklahoma State prediction, odds, time: 2026 Week 2 college football picks by proven model
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The SportsLine Projection Model has revealed its best bets for Oklahoma State Cowboys vs. Oregon Ducks on Saturday

By

Sep 11, 2026 at

9:15 am ET 2 min read

The No. 6 Oregon Ducks held off upset-minded Boist State in a 34-27 win in Week 1, and now they hit the road for the first time on Saturday. Heisman candidate Dante Moore threw for 378 yards and three touchdowns in the victory. The Oklahoma State Cowboys, meanwhile, are coming off a 24-10 road loss to Tulsa in Week 1 as first-year head coach Eric Morris and new starting quarterback Drew Mestemaker, both of whom came from North Texas, look for a better showing in Week 2. Visit our :

Kickoff is set for noon ET at Boone Pickens Stadium in Stillwater, Oklahoma. The Ducks are 23.5-point favorites in the latest Oregon vs. Oklahoma State odds, while the over/under is 55.5 points. Before making any Oregon vs Oklahoma State picks,  since the 2024 season, and it has been upgraded for the 2026 season to even better factor in the transfer portal. Anybody following its . You can and trends for Oklahoma State vs. Oregon:

Oregon vs. Oklahoma State spreadOregon -23.5
Oregon vs. Oklahoma State over/under55.5 points
Oregon vs. Oklahoma State money line Oregon -2174, Oklahoma State +1133
Oregon vs. Oklahoma State picks (Try for free)  
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Top Oregon vs. Oklahoma State predictions

After simulating Oregon vs. Oklahoma State 10,000 times, SportsLine's model is going Under (55.5 points) at the 
.

How to make Oregon vs. Oklahoma State picks

In addition to going Under on the total, the model also says one side of the spread hits more than 60% of the time. 
, and find out.

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