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2026 U.S. Open men's semifinal odds, predictions: Zverev-Khachanov, Tiafoe-Shelton picks by tennis expert

SportsLine's Jose Onorato reveals his U.S. Open best bets for Zverev-Khachanov and Tiafoe-Shelton in the men's semifinals

2026 U.S. Open men's semifinal odds, predictions: Zverev-Khachanov, Tiafoe-Shelton picks by tennis expert
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Tennis handicapper Jose Onorato has revealed his U.S. Open 2026 men's semifinal picks, predictions and best bets

By

Sep 11, 2026 at

7:35 am ET 3 min read

Only one of the top four seeds has advanced to the 2026 U.S. Open men's semifinals. World No. 2 and top-seeded Alexander Zverev will take on unseeded Karen Khachanov in Friday's first match, followed by No. 11 Frances Tiafoe facing off against No. 8 seed Ben Shelton. Zverev is looking to win his second Grand Slam event this year, after winning the French Open in June. He placed second at Wimbledon in July. Khachanov, Tiafoe and Ben Shelton are all seeking a spot in a Grand Slam final for the first time. Visit our :

The semis will start with Zverev vs. Khachanov at 3 p.m. ET from Arthur Ashe Stadium in Queens, N.Y. Zverev is the -500 favorite (risk $500 to win $100) to defeat Khachanov (+375) in the latest U.S. Open 2026 odds. The over/under for total games is 38.5 at .

Onorato grew up playing competitive tennis in Caracas, Venezuela. After coming to the U.S., he trained with famed coach Nick Bollettieri at IMG Academy in Florida and faced players like Robert Farah, now one of the world's top-ranked doubles players.

Onorato has gone 168-106-8 (+107.12 units) on his best bets since 2022. He correctly called Jannik Sinner in the 2025 Australian Open (+160), Carlos Alcaraz (+130) in the 2025 French Open and Sinner again at 2025 Wimbledon (+180). He also called Coco Gauff (+700) in the 2025 French Open, Iga Swiatek (+1200) at 2025 Wimbledon and then nailed Alexander Zverev (+700) at this year's French Open. Anybody following his tennis picks at sportsbooks and on . 

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2026 U.S. Open men's semifinal predictions

Onorato has analyzed both men's semifinal matches. One bet he is targeting at the .

Who wins the U.S. Open men's semifinals, and which bets should you target?

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